I assume your taking 221 from Marion to linville,I would just take 221 from linville to 105 into boone and pickup 421 in boone.You can ride it on your bike and decide yourself,you can get to the blueridge parkway from several places and ride it back ...
We're in the process of doing the same thing,kids are grown and we just didn't need all that room.and like you said theirs lots of places we've wanted to go for years that the 5th wheel was just to big.