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Novavax posted Phase 1 vaccine trial data. First-in-Human Trial of a SARS CoV 2 Recombinant Spike Protein Nanoparticle Vaccine Abstract Background NVX-CoV2373 is a recombinant nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins. We present the Day 35 primary analysis of our trial of NVX-CoV2373 with or without the saponin-based Matrix-M1 adjuvant in healthy adults. Methods This is a randomized, observer-blinded, placebo-controlled, phase 1 trial in 131 healthy adults. Trial vaccination comprised two intramuscular injections, 21 days apart. Primary outcomes were reactogenicity, safety labs, and immunoglobulin G (IgG) anti-spike protein response. Secondary outcomes included adverse events, wild-type virus neutralizing antibody, and T-cell responses. Results Participants received NVX-CoV2373 with or without Matrix-M1 (n=106) or placebo (n=25). There were no serious adverse events. Reactogenicity was mainly mild in severity and of short duration (mean ? 2 days), with second vaccinations inducing greater local and systemic reactogenicity. The adjuvant significantly enhanced immune responses and was antigen dose-sparing, and the two-dose 5?g NVX-CoV2373/Matrix-M1 vaccine induced mean anti-spike IgG and neutralizing antibody responses that exceeded the mean responses in convalescent sera from COVID-19 patients with clinically significant illnesses. The vaccine also induced antigen-specific T cells with a largely T helper 1 (Th1) phenotype. Conclusions NVX-CoV2373/Matrix-M1 was well tolerated and elicited robust immune responses (IgG and neutralization) four-fold higher than the mean observed in COVID-19 convalescent serum from participants with clinical symptoms requiring medical care and induced CD4+ T-cell responses biased toward a Th1 phenotype. These findings suggest that the vaccine may confer protection and support transition to efficacy evaluations to test this hypothesis. (Funded by the Coalition for Epidemic Preparedness Innovations; number, NCT04368988). 2 vaccine doses mild adverse reactions Induced 4x more antibodies than measured in serum from hospitalized covid-19 patients
BCSnob 08/07/20 10:34am Around the Campfire
RE: over nite stops

One thing to keep in mind is that truckers may 'run out of allowed driving time' Since my FIL is a driver and BIL is training (Covid concerns caused him to quit teaching) to be a driver I am aware of this issue.
BCSnob 08/06/20 08:01am Around the Campfire
RE: over nite stops

Were you arriving after 10pm and departing by 8am? If the CG is going to make me stay in an overflow parking area because I arrive after the start of quiet time what is the point of the added travel time from my route to the CG? How many CGs accept 6+ dogs?
BCSnob 08/06/20 07:17am Around the Campfire
RE: over nite stops

CGs are for people who are traveling for the experience of traveling or as home bases once they get to their vacation destination. We are eventers, we travel from home to the event site. While in route we will sleep in rest areas or other parking lots when we stop around 10-11pm local time. We’re only there long enough to rest. Finding and going to a CG at that time of night would add significantly to our travel time. Not all RVers in rest areas or parking lots are there to avoid the costs of a CG.
BCSnob 08/06/20 06:13am Around the Campfire
RE: covid gettin close ! (Personal Experiences)

Yea but majority of people who are impacted by Covid are elderly or already have health issues. At least 231 children and 29 adults who attended a Georgia overnight camp in June have tested positive for COVID-19, including 51 children under 10, and many who described feeling no symptoms. 597 Georgia residents, ages 6-59, attended the camp between June 17-27. The agencies were able to obtain test data for 344 people who attended the camp, with 260 (76%) of those testing positive. 231 children test positive for COVID after attending summer camp in Georgia, CDC says
BCSnob 08/01/20 02:52pm Around the Campfire

The vaccine uses a harmless-to-humans chimpanzee adenovirus as a delivery vector. That virus is modified to carry spike proteins from SARS-CoV-2—the component of the coronavirus that, in theory, should induce the sought-after immune response in humans. Source: Oxford's COVID-19 Vaccine Candidate Takes a Big Leap Forward, Showing Success in Early Trials Time Based upon this statement the vaccine has a whole chimp specific virus that has been genetically modified to have the part of the SARS-cov-2 virus that binds to the ACE2 receptors on human cells (key step in inducing an infection).
BCSnob 08/01/20 09:50am Around the Campfire
RE: Birthday Girl Nell

14 years old is really good since she was diagnosed with Addisons at about 6.
BCSnob 08/01/20 06:25am RV Pet Stop

Social Distancing Causally Impacts the Spread of SARS-CoV-2: A U.S. Nationwide Event Study Objectives: To assess the causal impact of a spontaneous relaxation of social distancing on the spread of SARS-CoV-2 in the United States (U.S.), while controlling for social mobility and state-imposed social distancing restrictions. Design: Event study. Setting: Quasi-experimental setting created by the U.S. nationwide protests precipitated by George Floyd's tragic death on May 25, 2020. Population: Individuals in 3,142 U.S. counties from all 50 states and the District of Columbia. Main Outcome Measures: The number of daily confirmed COVID-19 cases in all U.S. counties between the period of January 22, 2020, and June 20, 2020, and the cumulative change in COVID-19 cases in protest counties relative to non-protest counties following the onset of the protests. Results: We document a country-wide increase of over 3.06 cases per day, per 100,000 population, following the onset of the protests (95%CI: 2.47-3.65), and a further increase of 1.73 cases per day, per 100,000 population, in the counties in which the protests took place (95%CI: 0.59-2.87). The cause of the country wide increase in cases cannot be solely attributable to the protests because there were many other reported causes for increased cases at this time (for example: beach parties). The relative increase in locations where the protests occurred were likely attributable to the protests.
BCSnob 07/31/20 11:24am Around the Campfire
Birthday Girl Nell

Here is birthday girl Nell after her nightly walk. Nell just turned 14 and has a bit of arthritis. :( 14 year old Nell
BCSnob 07/30/20 05:47pm RV Pet Stop
RE: Florida

Think about the difficult decisions about who will receive hospital care when our health care system is at maximum capacity: young first, then first line responders, then single parents (or caregivers), etc. At the Top of the Covid-19 Curve, How Do Hospitals Decide Who Gets Treatment? If hospitals get overwhelmed, Florida is silent on who survives
BCSnob 07/30/20 12:50pm Around the Campfire

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus Cell Available online 3 July 2020 Coronaviruses have genetic proofreading mechanisms (Sevajol et al., 2014; Smith et al., 2013), and SARS-CoV-2 sequence diversity is very low (Fauver et al., 2020). Still, natural selection can act upon rare but favorable mutations. By analogy, antigenic drift results in gradual accumulation of mutations by the influenza virus during flu season, and the complex interplay between immunological resistance mutations and the fitness landscape enables antibody resistance to develop across populations (Wu et al., 2020), driving the need to develop new influenza vaccines every few seasons. ....there is no evidence yet of antigenic drift for SARS-CoV-2....
BCSnob 07/29/20 08:05pm Around the Campfire

I’ve not seen any studies which have shown mutations of sars-cov-2 on the spike proteins which would require different antibodies to confer immunity (analogous to the antigenic drift/shift that occurs continually in the influenza viruses). Based upon the study discussed above any studies showing declines in SARS-cov-2 antibodies need to be taken with a grain of salt if the identities of the declining antibodies are not determined (against the spike protein vs other portions on the virus). Searching for scientific publications can be done using Google scholar; the full publications on sars-cov-2 have been available for free.
BCSnob 07/29/20 07:35pm Around the Campfire

Humoral Response Dynamics Following Infection with SARS-CoV-2 In summary, this prospective cohort study of 137 longitudinally collected serological samples from 67 healthcare workers at Great Ormond Street Hospital has estimated that, in contrast to S-antibody, the half-life of IgG to N-antigen is only 52 days. Fifty percent will therefore have negative N-antibodies 195 days after the start of antibody decay. This has significant implications for sero-prevalence surveys that are based on the measurement of IgG to N-antigen in order to understand the spread of SARS-CoV-2 within the population. Data of this kind directly informs public health policy and responses to future waves of the pandemic. Policymakers relying on these estimates at a population level may need to be cautious, allowing for possible underestimation of the true prevalence of previous SARS-CoV-2 infection and/or exposure. Conversely, the trimeric S-antibody correlated strongly with ACE-2 receptor blockade and persisted longer with 50% of seropositive participants estimated to still test positive at 532 days (t1/2 81 days). This is reassuring for postvaccine licensure surveillance studies, given that current vaccine candidates are based on recombinant or fragments of S-protein.(45) Our upper bound for any detectable antibodies (S, RBD or N) following mild-to-moderate infection was 1495 days. This ongoing study is testing for how long covid-19 infected healthcare workers have measurable amounts of antibodies against SARS-CoV-2 after being infected. Viruses are much larger than antibodies. During an infection our bodies can produce antibodies to various parts of viruses; some of these antibodies will be against parts of the virus that is key to its replication within our body (neutralizing antibodies conferring immunity) and some antibodies will be against other portions of the virus that do not confer immunity. This study is measuring antibodies against three different parts of the SARS-CoV-2 virus (test manufactured by my employer). The study found that N-antibodies did not prevent biding of the ACE2 receptor (simulated infection test) and that the presence of these antibodies in a body decreased quickly while the S and RBD antibodies remained detectable for much longer and prevented binding of the ACE2 receptor. While this long term study is ongoing, they have projected (extrapolated from their current time points) how long 50% of their subjects are likely to still have detectable amounts of these three antibodies; for the s-antibody (one that provides protection in the simulated infection test) this time is 532 days post infection. This suggests immunity against SAR-CoV-2 for over 1 year post infection (and possibly post immunization). Another take away from this study is that not all antibody tests are the same. Tests against the N-antibody (used for most tests on the market) will provide some information about past infections (but not future immunity) and those whose infections were early in the pandemic may not be detected using the N-antibody. The antibody test used in this study measures four different antibodies against sars-cov-2, one for sars-cov-1, one for MERS, and four different seasonal flu strains all at the same time.
BCSnob 07/29/20 12:21pm Around the Campfire
RE: Dogs sniffing Corona

My guess is the dogs are detecting the presence of proteins produced by the body during inflammation in the response to an upper respiratory virus (any respiratory virus). What I’d like to know is at what point after infection the dogs can detect the infection; if before the onset of symptoms then dogs will be more effective and efficient than temperature checks.
BCSnob 07/29/20 10:49am RV Pet Stop

Moderna’s mRNA vaccine provided protection against SARS-CoV-2 in non-human primates. Experimental COVID-19 vaccine protects upper and lower airways in nonhuman primates NIH Covid-19 News Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates New England Journal Of Medicine Small brag about my day job from the NEJM publication SERUM ANTIBODY MEASUREMENTS Total SARS-CoV-2 S-2P–specific or N-specific IgG in serum was quantified by enzyme-linked immunosorbent assay (ELISA); the methods used were similar to previously published methods.6 ACE2 binding inhibition was completed, as described previously,16 on 1:40 diluted serum samples with the use of Mesoscale Discovery 384-well, 4-Spot Custom Serology SECTOR plates precoated with SARS-CoV-2 receptor-binding domain. Binding was detected with SULFO-TAG–labeled ACE2. Both reagents were supplied by the manufacturer (Meso Scale Diagnostics) free of charge.
BCSnob 07/29/20 10:11am Around the Campfire
RE: More water needed....

Is an motor home designed to carry 252# (30gal) directly on the roof structure with the bouncing that can/will occur while driving? Shouldn’t that load be carried on a roof rack attached to the roof above the walls where there is more structural strength?
BCSnob 07/28/20 01:43pm General RVing Issues

So frequently we have focused on the deaths per capita as an assessment of the relative severity of covid-19 vs seasonal flu. Another assessment can be the hospitalization rates for both diseases. 2019-2020 seasonal flu cumulative hospitalization rates: Rates per 100,000 0-4 yr 94.2 5-17 yr 24.3 18-49 yr 34.6 50-64 yr 90.5 65+ yr 174.1 CDC Laboratory Confirmed influenza hospitalizations Covid-19 (through July 18, 2020) Cumulative Rate per 100,000 Population Age Group 0-4 years 11.2 (12.3 July 25) 5-17 years 5.8 (6.4 July 25) 18-49 years 78.6 (85.5 July 25) 50-64 years 182.3 (196.3 July 25) 65+ years 338.2 (360.2 July 25) CDC Covid View Unlike seasonal flu where a plateau in hospitalization was reached at the end of the season, the hospitalization rates continue to increase for covid-19 because it is not behaving “seasonally”.
BCSnob 07/28/20 06:35am Around the Campfire

The only way to convince those who are willingly ignoring scientific evidence is for them to be personally impacted by what they are claiming is not a big deal. There have been and will continue to be examples of anti vaxxers who have been impacted by what the vaccine would have prevented (Anti-Vaxxer Mom Changes Mind After Her Three Kids Fall Ill). There have been and will continue to be those who say covid-19 is no different than seasonal flu who will end up hospitalized with covid-19 (like Arkansas senator Jason Rapert). But what happened to these people will be written off as rare cases by the “true believers” of the anti movements.
BCSnob 07/28/20 05:58am Around the Campfire
RE: Mostly for BCSnob : )

The $heep count is now 105 . Okay..... rounded up to 200.
BCSnob 07/27/20 04:14pm RV Pet Stop

New Zealand Immigrantion Travel to New Zealand New Zealand’s border is closed to most travellers and entry is strictly controlled. All arrivals are tested for COVID-19 and a 14-day managed quarantine or isolation is mandatory. Their daily new case curve is not only flat but has been near zero for over 2 months
BCSnob 07/26/20 05:38am Around the Campfire
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