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 > Your search for posts made by 'BCSnob' found 351 matches.

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My summary of these studies on protection against BQ.1.1: 1. 2. 3. Beautiful. Many thanks BC. Heading over to read. Been offline....just arrived in Florida on weekend.... Another study that assessed the rates of waning protection including natural immunity. Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 June 9 2022 N Engl J Med 2022; 386:2201-2212 I ask a question for which there isn’t an answer, yet. Why do some viral infections ,and the vaccines against these infections, produce years of protection while other viral infections, and the associated vaccines, only confer months of protection? (I am not referring to loss of protection with antigenic drift.)
BCSnob 11/25/22 07:43am Around the Campfire
RE: Goodnight Irene, the party's over.

Perhaps the bubble that developed during the pandemic has burst. 2020 vs 2019 shipments
BCSnob 11/23/22 05:55am General RVing Issues

I’ve seen a 3month follow up for Moderna mRNA-1273.214 (bivalent booster with BA.1). I don’t think the mRNA-1373.222 bivalent booster (BA.5) has been out long enough for publication of a 3month follow up.
BCSnob 11/21/22 07:49pm Around the Campfire
RE: Dealers lots are filling up

Did they also remove the book where two daughters get their father drunk so they could get pregnant? These same two daughters who were offered up for gang **** by their father. Seems like inappropriate reading for children and might be used to indoctrinate children.
BCSnob 11/19/22 03:25pm Tow Vehicles

DOI against which variant (or future variant)?
BCSnob 11/18/22 04:43pm Around the Campfire

Mex, don’t you need to know what type of mask (cloth, surgical, kn95, n95, etc) before you make such a statement (masking does little)? Do I need to repost the “real world effectiveness” studies on masks? I am currently not wearing masks because of my vaccination status and recent infection during BA.5 and community levels are low here. My parents wear masks 100% because my father has an autoimmune disease which minimizes his immune response to vaccination. One of my coworkers is wearing a mask because he will be visiting his grandmother soon and doesn’t want to inadvertently bring her Covid.
BCSnob 11/18/22 03:38am Around the Campfire
RE: USDA Announcement

Wildlife exposure to SARS-CoV-2 across a human use gradient BioRxiv preprint 7Nov2022 Abstract The spillover of SARS-CoV-2 into humans has caused one of the most devastating pandemics in recorded history. Human-animal interactions have led to transmission events of SARS-CoV-2 from humans to wild and captive animals. However, many questions remain about how extensive SARS-CoV-2 exposure is in wildlife, the factors that influence wildlife transmission risk, and whether sylvatic cycles can generate novel variants with increased infectivity and virulence. We sampled 18 different wildlife species in the Eastern U.S. and detected widespread exposure to SARS-CoV-2 across wildlife species. Using quantitative reverse transcription polymerase chain reaction and whole genome sequencing, we conclusively detected SARS-CoV-2 in the Virginia opossum and had equivocal detections in six additional species. Species considered human commensals like squirrels, and raccoons had high seroprevalence, ranging between 62%-71%, and sites with high human use had three times higher seroprevalence than low human-use areas. SARS-CoV-2 genomic data from an infected opossum and molecular modeling exposed previously uncharacterized changes to amino acid residues observed in the receptor binding domain (RBD), which predicts improved binding between the spike protein and human angiotensin-converting enzyme (ACE2) compared to the dominant variant circulating at the time of isolation. These mutations were not identified in human samples at the time of collection. Overall, our results highlight widespread exposure to SARS-CoV-2 in wildlife and suggest that areas with high human activity may serve as important points of contact for cross-species transmission. Furthermore, this work highlights the potential role of wildlife in fueling de novo mutations that may eventually appear in humans. Selected parts of the Discussion Our combined results suggest that a high diversity of species are exposed to SARS-CoV2 in the wild. Prevalence of active infections among wildlife was generally low and ranged from 1.6-20.0%. We found that 7.8% of opossums, a marsupial, were positive (including equivocal detections), similar to white-tailed deer (10.0%). The Eastern gray squirrel also had detections on both RT-qPCR (1.6%) and using serological tests (71.4%). Several other species that were examined for antibodies to SARSCoV-2 suggested high levels of previous exposure, including raccoons (64%) and skunks (67%). SARS-CoV-2 is being transmitted from humans to wildlife; there was greater rates of transmission in locations where there are more humans. Omicron variants of SARS-CoV-2 were detected in an opossum before those variants were detected in the local human population. Either the mutations developed in the opossum, or the opossum was infected from humans with this variant (and then sampled) before human sampling detected the new variant. Inadequate variant sampling of humans or human to opossum transmission followed by mutation within the opossum and then transmission back to humans.
BCSnob 11/08/22 06:43am RV Pet Stop
RE: We're getting ready........for lambing

We’ve had one die, an expensive ram.
BCSnob 11/06/22 09:44am RV Pet Stop
RE: We're getting ready........for lambing

The rams get 1 month of time with their ewe group this way we know lambing will only occur during 4 weeks (5 months from breeding). That time is now over. Yesterday we separated the rams from their ewe group and put the rams together in the field where they live. The rams now need to relearn to live together without the company of ewes. Maaaaaadddddd Rams There is no good way to stop this; they just need to sort things out. Yesterday we got confirmation Wendy is doing her job; the next door neighbor shot a large coyote overnight. Several coyotes of this size could take down an adult sheep.
BCSnob 11/06/22 05:28am RV Pet Stop

ok ty. Is there a vax for BQ 1.1? See Figure 2f of: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution BioRxiv Preprint 4 Oct 2022 ....thanks BC...I'm headin' over to read now..... Here is another one for you to read. It's a small study but it does measure the neutralizing antibodies (using a pseudovirus neutralization assay) produced against BQ.1.1 after Pfizer vaccination and Pfizer mono and bivalent boosting. Substantial Neutralization Escape by the SARS-CoV-2 Omicron Variant BQ.1.1 BioRxiv Preprint 2Nov2022 and another small study using either Pfizer or Moderna vaccinations (it's difficult to tell if these were homo or heterologous vaccinations) Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster BioRxiv Preprint 2Nov2022 and another study mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1 BioRxiv Preprint 1 Nov2022 My summary of these studies on protection against BQ.1.1: 1.boosting with the monovalent mRNA vaccines improves protection, but this protection wanes over time 2.boosting with the bivalanet mRNA vaccines provides better protection than the monovalent vaccines, but this protection wanes over time 3.previous infection with Omicron BA.5 provides better protection than the monovalent vaccines (depending upon severity of the infection), but this protection wanes over time
BCSnob 11/03/22 01:29pm Around the Campfire
RE: This net is dying!

As someone who has seen “stolen” photographs being sold I wonder who “owns” the photo uploaded via the photo app and is there support for those who own the copyright? Reporting Copyright/Trademark Infringement
BCSnob 11/02/22 01:35pm Around the Campfire

BCSnob 10/24/22 12:07pm Around the Campfire

ok ty. Is there a vax for BQ 1.1? No vaccine has been developed (reported) with a more recent variant than BA.4/5. One can get a sense of how protective the new bivalent (Wuhan + BA.4/5) vaccine from Moderna will be against a range of new variants by looking at the relative pseudovirus neutralization assay results for plasma from vaccinees (3 doses) who had BA.5 breakthrough infection. There was a 6.7x decrease in "protection" against BQ.1.1 as compared to protection against BA.5. See Figure 2f of: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution BioRxiv Preprint 4 Oct 2022
BCSnob 10/24/22 12:04pm Around the Campfire

This was the best info I found Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2 Cell Host & Microbe Volume 30, Issue 8, 10 August 2022, Pages 1093-1102.e3
BCSnob 10/21/22 01:41pm Around the Campfire

About the time the Moderna bivalent booster was available, we got boosted “naturally” (by BA.5, based upon prevalence). We’ll get the booster closer to the end of this year. My wife had cold symptoms while I had 24hrs of bad flu symptoms and a week of residual cough. Here is the preprint/publication I have found via google scholar on Moderna's mRNA-1273.222 (1:1 mix of mRNAs encoding the Wuhan-1 and BA.4/5 spike proteins). Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant Preprint 13Sep2022 Published: Nature Medicine 20 Oct 2022 Only transgenic mice data has been published.
BCSnob 10/21/22 07:47am Around the Campfire
RE: Comical EV article

Jimmy Patronis serves the citizens of the state of Florida as the state's Chief Financial Officer, State Fire Marshal, and member of the Florida Cabinet. He’s running for re-election; hard to know if he has a political agenda against EVs.
BCSnob 10/19/22 06:57pm Tow Vehicles
RE: Comical EV article

How many EV threads have been started by those opposed to EVs vs by those support the adoption of EVs? IOWs who keeps bringing it up? Don’t forget to count the deleted threads
BCSnob 10/19/22 03:40pm Tow Vehicles
RE: Heating the Garage

This article suggests 10 watts of heater output per square foot of garage space.
BCSnob 10/18/22 07:00pm General RVing Issues
RE: TFLEV gets disinformation from Cyber Truck fan bois.

As usual Mr. Snob you missed the point that Rivian will soon be toast. Someone needs to really read who is posting and what is being posted. Makes me wonder if you’re really all there.
BCSnob 10/11/22 06:44am Tow Vehicles
RE: EV charging quandry

BCSnob 10/09/22 05:34pm Tow Vehicles
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