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 > Your search for posts made by 'BCSnob' found 547 matches.

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RE: Chicken Before Egg?

Chickens are omnivores; if you see them go after a mouse, baby bird that has fallen out of a nest, etc you’ll see their dinosaur origins. I saw one the other day picking through the carcass of a coyote.
BCSnob 06/18/21 05:14pm Around the Campfire
RE: Chicken Before Egg?

:B
BCSnob 06/17/21 10:17am Around the Campfire
RE: Chicken Before Egg?

red junglefowl came first Man domesticated red junglefowl and developed the >100 breeds of chickens Here is a short list of breeds: OK State U Listing of Chicken Breeds
BCSnob 06/17/21 09:15am Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

Early evidence for the safety of certain COVID-19 vaccines using empirical Bayesian modeling from VAERS MedRxiv preprint doi: https://doi.org/10.1101/2021.06.10.21258589 Abstract The advent of vaccines against SARS-CoV-2 ushered in an unprecedented global response to COVID-19, with the largest and most ambitious mass vaccination campaign in human history. The scale of this effort means that safety signals suggesting adverse effects may only be detectable using passive reporting. This paper examines reports to the CDC/FDA’s VAERS system in the first six months of 2021, using an empirical Bayesian model with a gamma Poisson shrinker to identify potential safety signals from COVID-19 vaccines currently on the U.S. market. Based on this preliminary data, it is concluded that the COVID-19 vaccine’s safety significantly exceeds that of previously marketed vaccines, and other than a known risk of thrombotic events, no safety signals of concern emerge. A statistical analysis was performed using the VAERS system to assess the safety of covid-19 vaccines to other vaccines.
BCSnob 06/15/21 09:55am Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

During the phase 3 clinical trial of novavax’s covid-19 vaccine, the safety and immunogenicity of combining the covid-19 with the seasonal flu vaccines was tested. The preprint of this portion of the clinical trial was just posted. Safety, Immunogenicity, and Efficacy of a COVID-19 Vaccine (NVX-CoV2373) Co-administered With Seasonal Influenza Vaccines MedXiv preprint doi: https://doi.org/10.1101/2021.06.09.21258556 The first ~400 participants meeting main study entry criteria and with no contraindications to influenza vaccination were invited to join the sub-study. After randomization in a 1:1 ratio to receive NVX-CoV2373 (n=217) or placebo (n=214), sub-study participants received an age-appropriate, licensed, open-label influenza vaccine with dose 1 of NVX-CoV2373. Novavax covid-19 vaccine with flu vaccine or with placebo. Sub-study participants were younger, more racially diverse, and had fewer comorbid conditions than main study participants. Reactogenicity events more common in the co-administration group included tenderness (70.1% vs 57.6%) or pain (39.7% vs 29.3%) at injection site, fatigue (27.7% vs 19.4%), and muscle pain (28.3% vs 21.4%). Rates of unsolicited AEs, MAAEs, and SAEs were low and balanced between the two groups. Co-administration resulted in no change to influenza vaccine immune response, while a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. Vaccine efficacy in the sub-study was 87.5% (95% CI: -0.2, 98.4) while efficacy in the main study was 89.8% (95% CI: 79.7, 95.5). Mild reactions were more common in the group getting 2 vaccines than those getting the Covid-19 vaccine & a placebo. There was no difference in more serious reactions between the groups. The 2 vaccine group had slightly lower covid-19 efficacy (confirmed symptomatic mild or severe sars-cov-2 infection) than the covid vaccine & placebo group.
BCSnob 06/15/21 09:46am Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

This preprint posted today of a “ Multicenter observational cohort analysis Setting: Eight-hospital acute care regional health system in Michigan” addresses your second question in terms of how common and severe vaccine breakthrough case are. Vaccination reduces need for emergency care in breakthrough COVID-19 infections: A multicenter cohort study MedRxiv preprint doi: https://doi.org/10.1101/2021.06.09.21258617 This is part of the introduction. In the latest surge of COVID-19, the state of Michigan has been more severely impacted than the rest of the United States.1 In Michigan the volume of peaked to over 7,000 new daily cases between April 5th and April 12th 2021.13 According to the CDC, over a 2 week period ending April 24, 2021, 10 COVID-19 variants were detected within the region.14 The most common, B.1.1.7 variant, has been identified as the cause of over 50% of new COVID-19 diagnosis in the State of Michigan.14 While the B.1.1.7 variant has shown to be associated with increased transmissibility, to date there has been no evidence to suggest or negate the impact on vaccine efficacy. However, in-vitro studies have noted a loss in neutralizing activity by vaccine-induced antibodies when the E484K mutation was introduced to the B.1.1.7 variant.15 Results: 10,880 (91.9%) UV, 825 (7%) PV, and 129 (1.1%) FV were included. Average age was 53.0 +/- 18.2 and 52.8% were female. Accounting for the COVID-19 vaccination population groups in Michigan, the ED encounters/hospitalizations rate relevant to COVID-19 infection was 96% lower in FV versus UV (eB:0.04,95% CI 0.03 to 0.06, p <0.001) in negative binomial regression. COVID-19 EC visits rate peaked at 22.61, 12.88, and 1.29 visits per 100000 for the UV, PV, and FV groups, respectively. In the propensity-score matching weights analysis, FV had a lower risk of composite disease compared to UV but statistically insignificant (HR 0.84 95% CI 0.52 to 1.38). UV = unvaccinated PV = partially vaccinated FV = fully vaccinated Conclusions: The need for emergency care and/or hospitalization due to breakthrough COVID-19 is an exceedingly rare event in fully vaccinated patients. As vaccination has increased within our region, emergency visits amongst fully vaccinated individuals have remained low and occur much less frequently when compared to unvaccinated individuals. In cases of breakthrough COVID-19, if hospital-based treatment is required, elderly patients with significant comorbidities remain at high risk for severe outcomes regardless of vaccination status. The bolded statement in the conclusions may be of interest to you.
BCSnob 06/11/21 06:05am Around the Campfire
RE: What's up with Rocky Mt. National Park entry?

Perhaps the 1900s mission statement for the NPS should be updated for the modern more populous time and the increasing population of the future and focus more on preventing the adverse impacts of visitation on the land/natural resources it has been entrusted to preserve (wild lands, not a drive through safari park). How A Surge in Visitors Is Overwhelming America’s National Parks JULY 31, 2017 https://e360.yale.edu/assets/site/BrianHughes_HalfDome2006_330948.jpg A crowd waits to ascend the Half Dome in Yosemite National Park. BRIAN HUGHES/SUMMITPOST https://www.nps.gov/romo/learn/news/images/Gore-Range-to-Rock-Cut-congestion-7-24-16-Bonnie-Beach.jpg height=300 width=400 Trail ridge rd 2017
BCSnob 06/10/21 10:23am General RVing Issues
RE: What's up with Rocky Mt. National Park entry?

Are you willing to have a tax increase or a significant increase in entry fees to pay for the necessary infrastructure improvements to accommodate the increases in visitation?
BCSnob 06/10/21 10:04am General RVing Issues
RE: What's up with Rocky Mt. National Park entry?

I would prefer there was no one telling me when and what time I could enter the park. That goes against why the NPS was created! “For the benefit and enjoyment of the people”! As of last year and this year, they have taken that away from the US (and visitiors from other countries) citizens! You’re ignoring the part about “for future generations” which will be difficult to fulfill if the numbers of this generation are destroying or changing what is to be preserved for future generations.
BCSnob 06/10/21 08:58am General RVing Issues
RE: ISO a quiet place to go

What about boondocking on a farm which offers a few campsites? Perdue Homestead Farm There are other listing services besides hipcamp for these types of campsites Harvest Hosts is another listing site for free RV stays on farms, wineries, etc.
BCSnob 06/10/21 08:25am Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

WHO: MERS I can’t find info on new cases of sars-cov-1 The seasonal coronaviruses are causes of “colds” but I don’t think they are the only causes of “colds”
BCSnob 06/08/21 09:43am Around the Campfire
RE: Dog fence when sitting outside camper with dog

No! 4 nights ago, the neighbors in the next camp site over tethered their 80+ pounder on a spiral screw in stake in the ground. It charged me and my dog and popped the stake right out of the ground. It wasn't pretty. I doubt the outcome with this dog/owner would have been any different if this dog had been on a leash. I suspect the dog would have pulled the leash out of the owner’s hand. An inattentive owner using a tether in place of training to control their dog.
BCSnob 06/08/21 05:46am RV Pet Stop
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

This peer reviewed published study found that there was cross reactivity between the antibodies against SARS-CoV-2 and SARS-Cov-1, MERS, and two seasonal coronaviruses. Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform PLOS ONE June 3, 2021 https://doi.org/10.1371/journal.pone.0252628 These data support the idea that a universal coronavirus vaccine could be developed. BTW, this study used one of my employer's antibody testing products.
BCSnob 06/07/21 12:22pm Around the Campfire
RE: Our March Madness

We haven’t seen the bald eagles in a while; I’m not too disappointed about this. An Idaho farmer’s sheep kept dying. The culprit? Bald eagles nesting near his pasture Idaho Statesman 54 lambs kill this year.
BCSnob 06/02/21 02:17pm RV Pet Stop
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

This preprint of a study ifound that immunization and infections to one coronavirus (common cold, sars-cov-1, Mers etc) produced antibodies and T cells that cross react with the other coronaviruses. The authors suggest that one universal coronavirus vaccine could be developed. SARS coronavirus vaccines protect against different coronaviruses
BCSnob 06/02/21 06:42am Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

WHO announces simple, easy-to-say labels for SARS-CoV-2 Variants of Interest and Concern WHO See this link for the list of variants and the new names. WHO: Tracking SARS-CoV-2 variants
BCSnob 06/01/21 01:57pm Around the Campfire
RE: 2019–20 CORONAVIRUS PANDEMIC POSTINGS

Here is a preprint on a double-blinded study to evaluate the sensitivity (detection of true infections) and specificity (correctly identifying non-infections) of trained dogs and electronic sensors to detect the odors emitted from SARS-CoV-2 infected patients including asymptotic and mild infections (as identified by PCR). 3,921 adults were enrolled in the study and odour samples collected from 1097 SARS-CoV-2 infected and 2031 uninfected individuals. OSC sensors were able to distinguish between SARS-CoV-2 infected individuals and uninfected, with sensitivity from 98% (95% CI 95-100) to 100% and specificity from 99% (95% CI 97-100) to 100%. Six dogs were able to distinguish between samples with sensitivity ranging from 82% (95% CI 76-87) to 94% (95% CI 89-98) and specificity ranging from 76% (95% CI 70-82) to 92% (95% CI 88-96). The dogs were trained using odor from patients infected with the original variant but there was no evidence during the double blinded test that infections with the B.1.1.7 variant affected the dogs from correctly identifying infected patients. A relatively narrow range of sensitivity and specificity was apparent between the different dogs tested. In practice, only the highest performing dogs would be deployed. Our results suggest, however, that, in this experimental setting, the dogs had a higher accuracy than the LFT (lateral flow test, strip test like a pregnancy test) which has a wider range and lower overall sensitivity of between 58-77%.29 RT-PCR is the gold standard test due to a high sensitivity (97-99%) and specificity (95-99%),30 but dogs have a major advantage over both these tests as they are incredibly rapid. Our preparatory work indicates that two dogs could screen 300 people in 30 min, for example, the time it takes to disembark from a plane, and PCR would only need to be used to test those individuals identified as positive by the dogs (Figure 4). The authors address some limitations in their study. Our study has a number of limitations. Firstly, although dogs could be used to screen samples, the real value would be screening people, and we have not yet tested dogs on people infected with SARS-CoV-2. Secondly, our results suggest dogs are able to detect the B.1.1.7 variant, although the sample size was not sufficient for a reliable estimate of sensitivity. In the event that a new variant of SARS-CoV-2 resulted in a different odour profile, trained dogs could be rapidly re-trained to detect the new odour within two days providing odour samples for the new variant are available. Thirdly, there is a possibility that other respiratory viral infections produce similar odour signatures to SARS-CoV-2. This is, however, unlikely given that 26% of uninfected participants in our study displayed classic SARS-CoV-2, cold or flu-like symptoms, and the dogs correctly identified them as uninfected. Additionally, other studies suggest that different viral infections result in distinct odour profiles.9,10, 11 ,12 So why dogs vs electronic sensors? Sensors can detect the presence of the odor; dogs can track the odor to the source within a crowd. I saw a news article that dogs scent trained to marijuana were being retired due to the changing laws; if this is true perhaps these proven scent dogs could be retained to detect SARS-CoV-2. Using trained dogs and organic semi-conducting sensors to identify asymptomatic and mild SARS-CoV-2 infections
BCSnob 06/01/21 12:34pm Around the Campfire
RE: Could the weather get any more miserable?

We have lovely weather today, sunny low 70s with a cool breeze. Perfect weather for putting in fence posts.
BCSnob 05/31/21 07:09am Around the Campfire
RE: Could the weather get any more miserable?

On my commute home Friday afternoon the radio was reporting golf ball sized hail along I66 west of DC associated with a supercell they were monitoring for rotation as it approached DC. Fortunately no tornado developed. Fortunately that cell stayed south of my commute home.
BCSnob 05/30/21 05:03pm Around the Campfire
RE: Could the weather get any more miserable?

I went to the Indy 500 once, 1976; the weather wasn’t pleasant. The race was ended after ~102 laps.
BCSnob 05/30/21 11:44am Around the Campfire
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