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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
.....interesting pre-print. However, the investigators point out importantly vis modeling:
"...the immunity landscape is more complex than this SIRS model can capture. This complexity arises due to heterogeneity in individual exposure to infection and vaccination, interindividual variability in antibody durability, and neutralizing antibody build-up over successive infections and vaccinations..."
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silversand
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02/03/23 12:14pm |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
....I can't help but to think about the early sars-cov-2 point mutations and designing for "the spike", and how at Omicron and beyond, recombinant new variants now apply pressure on mRNA vaccine approaches (rapidity of new mRNA formulations, playing catch-up, etc).
Also, has anyone considered T suppressor lymphocytes inhibiting the immune response after rapid interval vaccination? Any papers on this?
And, why can't we develop mucosal immunity antivirals, rather than systemic injectables (for example, vis this new recombinant sars = beyond Omicron, seems to be a mucosal infection to me, not systemic) ?
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silversand
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02/03/23 11:33am |
Around the Campfire
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RE: ARE THERE ANY SNOWBIRDS ANYMORE?
It is estimated the the snowbird population around the Quartzsite area alone is in the 500,000 range. Mesa's population swells in the winter, causing waiting lines at restaurants to go out the door
....Interesting. I wonder how many of the ~500,000 Quartzsite "snowbirds" (guestimate: almost all are boondockers) actually stay in Arizona, all year 'round (ie. they migrate from Quartzsite to BLM land in the high country when Quartzsite gets too hot) ?
I think (don't quote me) that Arizona has the 9th fastest growing population in the US (Florida is ranked 5th fastest growing)
We are "snowbirding" in an ocean front condo (Butler Beach, near St Augustine), however, after the condo, we have a park model rented in March that is water-front on the intercoastal. Too expensive to haul an RV down here from Canada....at this juncture.
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silversand
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02/03/23 07:41am |
Snowbirds
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
"In addition to the clinical report of infections, we measured anti-nucleocapsid (anti-N) antibody responses in all individuals to determine potential undiagnosed infection with SARS-CoV-2"
From, "Durability of immune responses to the booster mRNA vaccination against COVID-19"
....!
On edit:
Just now reading and beyond, "Electrochemiluminescence (ECL) binding enzyme-linked immunosorbent assay for anti-Spike and anti-nucleocapsid antibodies"
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silversand
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12/11/22 07:06am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
(read how the antibodies were measured)
.....thanks. Heading over to read today
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silversand
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12/11/22 06:56am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
...anecdotal, and local to our condo complex in North Florida:
21 close friends here. Only 1 has been symptomatic with cold-like symptoms over past 15 days. This person had JUST arrived back here at the complex from Vermont, WITH cold-like symptoms (and self isolating on the beach in open air and 74F sun. All other of our group who have been here in Florida for weeks or months: healthy, no cold or flu-like symptoms....yet. Still monitoring.
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silversand
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12/04/22 06:27am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
" In a 2018 review of 11 recent studies on the durability of influenza vaccines, researchers concluded that effectiveness can vanish as soon as 90 days after vaccination. The article, published in Clinical Infectious Diseases, further noted that 20% of Americans received their flu vaccines for a given season by the end of September—which means the vaccine may do nothing come peak flu spread in January and February."
This, quoted from, How Long Do Vaccines Last: Scientists are developing vaccines that produce more durable immune responses and debating when booster shots are needed
This doesn't answer the question you ask, however it is an easy to read article that any layman can understand towards getting familiar with the subject of waning durability; published in the journal Science:
here-->
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silversand
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11/30/22 05:57am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
....this is interesting. I was tipped off to the article at Eric Topol's blog:
This, published less than a week ago in the prestigious research journal, SCIENCE Vol 378, Issue 6622:
"Competition between respiratory viruses may hold off a ‘tripledemic’ this winter"
here-->
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silversand
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11/25/22 04:53am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
....I found this article to be incredibly interesting:
"'Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.'"
National Center for Biotechnology and Information
here-->
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silversand
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11/22/22 12:10pm |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
My summary of these studies on protection against BQ.1.1:
1.
2.
3.
Beautiful. Many thanks BC. Heading over to read. Been offline....just arrived in Florida on weekend....
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silversand
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11/22/22 12:03pm |
Around the Campfire
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RE: For POP UP CAMPER owners - sealing seams on vinyl
...I used Seam Grip (crystal clear) on the **Weblon** soft walls (I don't know what your softwalls are made of, so do your due diligence before applying) on our pop-up truck camper window stitching (the window bottom stitches). That was almost 17 years ago. The Seam Grip is still in perfect shape after all this time (we still own the 2005 camper). I never had to re-seal in all these years.
But be aware: you REALLY need to investigate where the stitching leaks are. I found our water beads (not terrible leaks) during a post-tropical storm in the Outer Banks, when the rain was coming down sideways in 54 mile per hour driving storm.
Just be sure that the water infiltration isn't coming in along the vertical stitches somewhere!
Caution: Seam Grip volatiles smell like he**. And, it is flammable until it dries. I applied it on our inside stitching (seems to work perfectly in our situation). You may want to consider applying to the exterior stitching. If you use this, you had better practice on stitching not associated with your camper (some scrap stitching on some vinyl). You cannot remove this stuff if you mess up the application technique. Also, the cured material will darken slightly after 4 to 5 years (unless they changed the formulation since 17 years ago).
Good luck. This worked for us. Your mileage may vary.
Seam Grip: here-->
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silversand
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11/10/22 05:15am |
Truck Campers
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RE: Google Maps Toll Prices
....cheers Moisheh. Wishing ya a safe drive this fall to MX.
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silversand
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11/01/22 08:19am |
RVing in Mexico and South America
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RE: Google Maps Toll Prices
....I never considered using a complex toll app for Mexico (or, covering the US) as our rigs are SUV and 2500HD (pick-up) carrying truck camper. No dually, no towing.
I did more digging, and came up with an app that calculates:
-Auto: select from 2-axle cars, SUV, Carpool, Pickup with four tires, 6-tires, and 1-axle trailer attached.
-Truck: select from 2-axle trucks to 9-axle trucks. Enter the height and loaded weight of your truck.
-Bus: Choose between 2-axles or 3-axles. Enter height and loaded weight of the bus.
-RV or motorhome: Select whether you have a 1-axle trailer. Enter height and loaded weight.
-Motorcycle: Select whether you have a 1-axle trailer.
I never used it. It is called TollGuru. You can play with the interface, and enter exotic RV combos like motorcycle towing mini trailer; RV hauling double-axle trailer, etc, etc
here-->
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silversand
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10/31/22 07:21am |
RVing in Mexico and South America
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RE: Google Maps Toll Prices
:)
Great. I'm loading this app on my phone and tablet...
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silversand
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10/30/22 07:24am |
RVing in Mexico and South America
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RE: Google Maps Toll Prices
....anyone ever try out TollSmart? It advertises as a free toll calculator (Apple and Android) for passenger cars (2 axle) Canada, USA and Mexico (and Brazil). here-->
I'm going to try it in a month for Canada and USA accuracy.
Reading an article on TollSmart providing its toll price data to Google Maps for drivers in the US...
On edit: .....I'm trying TollSmart's web browser app to calculate a US stretch of tolls that I already know. 100% accurate. Now, I'll try Nuevo Laredo to Monterrey, via 85D.....drum roll....282.00 MEX. Does this sound correct?
TollSmart trip calculator here-->
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silversand
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10/28/22 08:39am |
RVing in Mexico and South America
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
ok ty. Is there a vax for BQ 1.1?
See Figure 2f of:
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
BioRxiv Preprint 4 Oct 2022
....thanks BC...I'm headin' over to read now.....
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silversand
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10/28/22 08:26am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
....OK....Mex:
....I'm keeping my eye on the GIS-RS FluNet, and notice that the US has submitted data ending October 16th (called: week number 41).
Flu "activity" in the US appears to be ramping up (Canada, too); however see my * asterisk below. With Canadian sample specimens tested at 285 (125 specimens returning A(H3) ) ....compare with Oct 2nd specimens at ~96 (35 specimens returning A(H3) ). In the US week ending Oct 16th, 75 specimens returning B (lineage undetermined), and 2685 specimens A (lineage undetermined) and 69 returning A(H3). Back week ending Oct 2nd in US: 1470 total specimens (mostly A (lineage undetermined) and a sprinkle of B)....and week ending Sept 4th USA: appx 450 specimens total (A + B)....
*the quantity of specimens may not represent an spatially uniform or accurate accounting of the "trend" in FluNet
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silversand
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10/28/22 08:21am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
....nope, not specifically the BQ.1.1 lineage (mutations ORF1b-N1191S and S-R346T). Nor the BQ.1.4 (England and Denmark, defined by S-R190T).
But as always, consult your physician for vaccine options.
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silversand
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10/24/22 09:33am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
silversand,
B 1.1 but I may be wrong.
....OK....you may mean BQ1.1 as B (or, BA 1.1) seems to be extinct in the EU, Canada, Mexico, USA and even Japan. The new BQ animal has reached appx 10% in the USA presently (varying widely spatially by region), and in Canada, 4.9% share of animals and rising rapidly (displacing BA4 and 5) according to CoVariants.org
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silversand
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10/24/22 08:44am |
Around the Campfire
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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
I've already chosen the local jab for next week.
If memory serves me correctly that strain was H1N1
....Mex: isn't the prevailing global flu strain presently the A (H3) ?
On edit: ....I am reading that the two flu shots recommended for 65+ years of age are: Fluad Quadrivalent, or Fluzone high-dose quadrivalent.... (https://www.goodrx.com/)
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silversand
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10/24/22 08:25am |
Around the Campfire
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