Don,
Your E450 probably does - just use the MIX airflow knob setting, turn the temperature knob into the blue area to turn on the A/C compressor mode instead of the red area for the heating mode, then turn the fan speed to 3 or 4.
The MIX setting routes all the airflow to be from only the defrost vents and the floor vents ... while at the same time shutting off completely the air flow out of the chest level outlets.
What you then get in the cab is cold air coming out the defrost openings and gently flowing/bathing down over the driver and passenger to keep the whole cab cool without cold air blasting them in the face and upper body - just a feeling of cool comfort that seems to be coming from "everywhere".
What you also get is nice cool feet and lower body due to air conditioned air from down below at the foot vents swamping out doghouse heat and/or floor heat.
All this works like a champ - but it takes getting used to this new feeling of overall cab coolness instead of feeling jets of cold air blasting directly on you. You must have the fan setting on 3 or 4, as the lower fan speeds won't move enough cool air to create the effect.
P.S. Even without doing the above air routing, our cab floor is never too hot anyway due to the heavy floor covering it came with plus the metal heat shields underneath mounted between the exhaust pipes and the bottom of the cab floor. I don't know if Winnebago or Ford installed those shields.
2005 E450 Itasca 24V Class C