Let's see...if travelling across New York state, Letchworth State Park has beautiful scenery and lots of hiking that isn't too demanding. Watkins Glen is neat, too, and very much in New York wine country. The Adirondiacks in general are lovely, too.
Vermont has the most craft breweries per capita of any state. New England in general is something of a hotbed of microbrew activity.
There's a good bit of hiking in the area. Some of my favorites in Vermont include Camel's Hump (partly because it's just down the road), which is a reasonably strenuous day hike but offers stunning views on a clear day; the trail system through Groton State Forest in the Northeast Kingdom, many of which are not mountianous; and Mount Ascutney, which is a pretty strenuous hike if you climb the mountain, or a relatively sedate stroll around the top if you drive the auto road up. There are many, many others. The Kancamagus Highway in New Hampshire is a lovely drive and has many trails and lookouts to stop at, ranging from brief easy strolls (e.g. Sabbaday Falls) to full day hikes or perhaps longer.
The Shelburne Museum (Shelburne, VT) is large, interesting, and quite eclectic, probably best categorized as folk art if anything. I kind of like the Fairbanks Museum in St. Johnsbury, VT, which is basically a natural history museum with some miscellaneous other exhibits, and in some ways is kind of a "museum museum" in that it hasn't changed a whole lot in the better part of a century. The library (Athenaeum) in St. Johnsbury also has a very nice little art gallery.