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 > 2019–20 CORONAVIRUS PANDEMIC POSTINGS

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hokeypokey

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Posted: 07/02/20 02:59pm Link  |  Quote  |  Print  |  Notify Moderator

My hair salon has an advertised rule. Wear a mask. My hairdresser said a man came in demanded a haircut but refused to wear a mask. Caused a big scene & left with no haircut. Now what did he gain ?

jetboater454

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Posted: 07/03/20 03:52am Link  |  Quote  |  Print  |  Notify Moderator

hokeypokey wrote:

My hair salon has an advertised rule. Wear a mask. My hairdresser said a man came in demanded a haircut but refused to wear a mask. Caused a big scene & left with no haircut. Now what did he gain ?


He didn't gain anything. BUT....if he was raising his voice or yelling,he was possibly infecting people farther than the 6' distance. I hardly wear a mask,but I'm not usually within 20' of people. Closer than 10' I mask up.


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MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 07/03/20 10:19pm Link  |  Quote  |  Print  |  Notify Moderator

In the age of cigarette smoking, I used to blanch in horror at the enormous size of the blue clouds especially if they were backlit by sunlight. I remember how far the smoke traveled if the smoker blew the smoke or coughed.

The analogy is useful. If the virus was like smoke I remember gagging as I threaded my way through the bar to the dining room. Supposedly the virus is like the smoke: Only when the concentration the density of smoke gave a person a headache: The virus can be deadly.







i remember

BCSnob

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Posted: 07/04/20 01:56pm Link  |  Quote  |  Print  |  Notify Moderator

Visualizing the effectiveness of face masks in obstructing respiratory jets

A study emulating coughs and the distance the expelled droplets can travel, 12’ in 50secs (farther than the recommended 6’ social distance). The impact of various masks on the coughed droplets was assessed. There was a significant reduction in the distance the coughed droplets traveled and the effectiveness was dependent upon mask design.


This is an important quote from this article.
Quote:

Several studies have investigated respiratory droplets produced by both healthy and infected individuals when performing various activities. The transport characteristics of these droplets can vary significantly depending on their diameter.23–28 The reported droplet diameters vary widely among studies available in the literature and usually lie within the range 1 µm–500 µm,29 with a mean diameter of ?10 µm.30 The larger droplets (diameter >100 µm) are observed to follow ballistic trajectories under the effects of gravity and aerodynamic drag.20,31

I read so many comments in yahoo about how masks can not filter the virus because the virus is too small. While the virus by itself is small enough to not be filter it is expel during coughs, sneezes, or talking in droplets which are large enough to be filtered by masks. This is like arguing mosquito is ineffective at preventing the spread of malaria because malaria is small enough to pass right through the netting.

* This post was edited 07/04/20 02:21pm by BCSnob *

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Posted: 07/04/20 04:01pm Link  |  Quote  |  Print  |  Notify Moderator

Hydroxychloroquine trials stopped after failure to reduce death.

Turtle n Peeps

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Posted: 07/04/20 04:42pm Link  |  Quote  |  Print  |  Notify Moderator

Hydroxychloroquine cuts death rate significantly in Ford study.


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BCSnob

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Posted: 07/04/20 05:46pm Link  |  Quote  |  Print  |  Notify Moderator

Peer reviewed published studies should be provided even if they give conflicting results to other studies.

Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19
International Journal of Infectious Diseases
Samia Arshad
Paul Kilgore
Zohra S. Chaudhry
William O’Neill
Marcus Zervos
Henry Ford COVID-19 Task Force

Quote:

Results

Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with median time to follow-up of 28.5 days (IQR:3-53). Overall in-hospital mortality was 18.1% (95% CI:16.6%-19.7%); by treatment: hydroxychloroquine?+?azithromycin, 157/783 (20.1% [95% CI: 17.3%-23.0%]), hydroxychloroquine alone, 162/1202 (13.5% [95% CI: 11.6%-15.5%]), azithromycin alone, 33/147 (22.4% [95% CI: 16.0%-30.1%]), and neither drug, 108/409 (26.4% [95% CI: 22.2%-31.0%])?.


In this peer reviewed published study, using their drug doses and their supportive care, hydroxychloroquine was found to reduce mortality from Covid-19. The authors clearly stated the limitations of their findings:
Quote:

Limitations to our analysis include the retrospective, non-randomized, non-blinded study design. Also, information on duration of symptoms prior to hospitalization was not available for analysis.

The authors also discussed the variable performance of this drug reported from other studies.
Quote:

Recent observational retrospective studies and randomized trials of hydroxychloroquine have reported variable results. (Gautret et al., 2020a, Gao et al., 2020, Gautret et al., 2020b, Jun et al., 2020, Tang et al., 2020, Chen et al., 2020, Yu et al., 2020, Geleris et al., 2020, Rosenberg et al., 2020, Magagnoli et al., 2020, Million et al., 2020) In a randomized controlled study of 62 patients from China with COVID-19, hydroxychloroquine was associated with a shortened duration of fever and time to cough and pneumonia resolution (Chen et al., 2020). In contrast, a study of 1376 consecutive hospitalized COVID-19 patients in New York that used respiratory failure as the primary endpoint found no significant reduction in the likelihood of death or intubation among those receiving hydroxychloroquine compared to those who did not. (Geleris et al., 2020) In a separate multicenter cohort study of 1438 patients from 25 hospitals in New York, no reduction in hospitalized patient mortality was observed with hydroxychloroquine treatment (Rosenberg et al., 2020). Among a number of limitations, this study included patients who were initiated on hydroxychloroquine therapy at any time during their hospitalization. In contrast, in our patient population, 82% received hydroxychloroquine within the first 24?hours of admission, and 91% within 48?hours of admission. Because treatment regimens likely varied substantially (including delayed initiation) across the 25 hospitals that contributed patients to the study, it is not surprising that the case-fatality rate among the New York patients was significantly higher than in our study.


The authors also state:
Quote:

our results should be interpreted with some caution and should not be applied to patients treated outside of hospital settings. Our results also require further confirmation in prospective, randomized controlled trials that rigorously evaluate the safety, and efficacy of hydroxychloroquine therapy for COVID-19 in hospitalized patients.


The authors also clearly stated this drug should not be given outside of a hospital setting where the patients can be monitored for the serious side effects.

* This post was last edited 07/04/20 06:24pm by BCSnob *   View edit history

dturm

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Posted: 07/05/20 05:26am Link  |  Quote  |  Print  |  Notify Moderator

The problem with people/press who are not used to reading and interpreting medical/scientific studies is illustrated here. The tendency is to look for a study that supports your preconceptions and read the headlines and use that as proof that your position is correct.

This type of study (retrospective, non-randomized, non-blinded study) has the least value when trying to make decisions based on the evidence. Some value, but not much more than a footnote.

The fact that the WHO has suspended hydroxychloroquin studies has much more value when making informed decisions.


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BCSnob

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Posted: 07/05/20 05:50am Link  |  Quote  |  Print  |  Notify Moderator

From what I can tell about the WHO trial, it was of similar design as the one by the Henry Ford (not double-blinded). I’ve not been able to find info of dosing or when during the illness the patients were started on the selected treatments. Both studies have likely come to the correct conclusions based upon the subtle differences in their protocols and patient populations (underlying health issues) being treated and even perhaps the strains of the virus causing the infections.

I think what is obvious is the the drugs in these studies are not definitive treatments since it appears subtle differences in protocols impact effectiveness.

dturm

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Posted: 07/05/20 06:30am Link  |  Quote  |  Print  |  Notify Moderator

WHO determination was not based on one study but of multiple ongoing trials according to their press releases. I have not read any of the studies, so I'm basing my information on the press (could be a dangerous thing to do [emoticon])

Quote:

“These interim trial results show that hydroxychloroquine and lopinavir/ritonavir produce little or no reduction in the mortality of hospitalised COVID-19 patients when compared to standard of care. Solidarity trial investigators will interrupt the trials with immediate effect,” the WHO said in a statement, referring to large multicountry trials that the agency is leading.


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